Description
Product Characteristics: Bub1 is a serine-threonine protein kinase and an important regulator of cell division. It is essential for the G2/M mitotic spindle assembly/integrity checkpoint as well as critical for chromosome alignment. Bub1 is required for the assembly of a large number of proteins at the kinetochore, including CENP-E, CENP-F, BUB1B, MAD2L1 and PLK1. It plays a role in sister chromatid cohesion and it serves as a substrate for the anaphase-promoting complex. Bub1 mediates cell death in response to chromosome mis-segregation and acts to suppress spontaneous tumorigenesis.
Target Information: This gene encodes a kinase involved in spindle checkpoint function. The kinase functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer. [provided by RefSeq, Jul 2008]